essential guide to prescription drugs

Female sexuality flies with flibanserin or is this a "made up" medicine?

bicycle on beach Flibanserin (Fluh BAN ser ihn) for female sexual desire has been a controversial medicine, possibly because of the way it works (increasing blood flow to the genitals), but more broadly, because of the condition (hypoactive sexual desire disorder- HSDD) that the medicine might treat.

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bicycle on beach Flibanserin (Fluh BAN ser ihn) for female sexual desire has been a controversial medicine, possibly because of the way it works (increasing blood flow to the genitals), but more broadly, because of the condition (hypoactive sexual desire disorder- HSDD) that the medicine might treat. Controversy surrounds HSDD and if it is a made up problem to sell medicines or if it is something that is a real problem which a significant number of women face.

Today, however is the day when the expert panel is meeting to take a very close and considered look. Is this a female Viagra? Should we care? History tells us that HSDD has been recognized as a problem for up to 7 % of women for about 40 years.

man and woman looking at beach The drug works on three chemicals known as neurotransmitters. Dopamine, serotonin and norepinephrine affect the brain's reward center and ability to feel pleasure in a way that researchers admitted to the meeting they don't fully understand. Side effects include sleepiness, fainting and fatigue, but these issues can be dealt with by taking the pill at bedtime.

It will be interesting to see how the panel votes today and if they recommend the medicine, if the FDA will follow the panel advice and approve it. I'll include data on this medicine in the upcoming Essential Guide to Prescription Drugs and may create a stand alone eBook if there is enough demand.

Polio virus and cancer treatment?

cannon Polio and cancer?

Sounds like an unlikely combination, but the idea of using viruses to attack cancer cells has been around for a long time. Where was the technology? Still to be developed.

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cannon Polio and cancer?

Sounds like an unlikely combination, but the idea of using viruses to attack cancer cells has been around for a long time. Where was the technology? Still to be developed.

Enter genetic engineering and what appears to be a great new cancer weapon. Researchers at Duke (Preston Robert Tisch brain tumor center) engineered a poliovirus called PVS-RIPO. The approved clinical studies in 2012 and 5 brain tumor (difficult to treat and widespread) patients were selected. One patient had such a great response, she is back teaching school.

This appears to be the ultimate targeted therapy in that normal cells are not injured, unlike a lot of currently available chemotherapy. This treatment infects the cancer cell and kills it.

More at www.clinicaltrials.gov and www.fda.gov and here as information emgerges. I'll update this information in the upcoming Essential Guide to Prescription Drugs full edition in the Leading Edge section.

Mysimba (Contrave-Naltexone plus bupropion in the EU) now approved for weight loss

Mysimba for weight loss- It is the name for Contrave (naltrexone and bupropion) in Europe. This drug is the newest weight loss drug and had an unusual release of data. What appears to be shown in early data is that it may have a direct effect/benefit in decreasing risk of heart attack.

Palcohol powdered alcohol approved and now not approved

 

young women drinking Palcohol. Powdered alcohol. Convenient for hikers, kayakers, anywhere where weight is an issue, but could the very convenience it brings increase risk of alcohol poisoning and under age drinking?

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young women drinking Palcohol. Powdered alcohol. Convenient for hikers, kayakers, anywhere where weight is an issue, but could the very convenience it brings increase risk of alcohol poisoning and under age drinking?

These appear to be the challenges that Lipsmark, the company that makes Palcohol and Mark Phillips, the company president are now facing.

In a recent interview, the president noted that he came up with the idea for use in hiking and wanting to enjoy an alcoholic beverage when the day is done. One of the Rum, Vodka, Cosmopolitan or Powderita packets apparently has as much alcohol as a typical drink. The prevalent video shows Mr. Phillips reconstituting a packet, then pouring a drink.

 

Concerns arose in the media and from legislators almost immediately. Colorado and several other states banned the product. Approval for the product apparently has been reversed.

This editor immediately had the caution reaction, noting that the recently released Essential Guide to Prescription Drugs, Update on Alcohol helps people understand how to drink safely and avoid interactions, but that the book didn't contain Palcohol data (except in the sense of a standard drink and being careful of intake).

 

The saga of Palcohol is not over, but is apprently being reviewed. There are several cases of prescription drugs where medguides (and perhaps the Essential Guide) could be used to teach people about the product and help avoid problems. Perhaps a limitation on sales (5 packets at a time to any single person) could help.

 

More to follow as always once new information becomes available.

Contrave and cardiology--could this newer weight loss drug help your heart too?

food

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food Contrave (bupropion and naltrexone) is apparently unique. The SEC disclosed that the US patent office gave the 371 patent to Orexigen Therapeutics based on an interim look at the LIGHT study. What this means is that Contrave has a claim for having a POSITIVE IMPACT on cardiovascular results (outcomes) beyond (unrelated to) weight loss.

More to come and most probably from the American College of Cardiology meeting in San Diego this month. Regardless, having strength in weight loss AND HEART disease is a true breakthrough in medicines.

If the medicine looks defective should you ever give it?

 

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phone A scheduled lethal injection of a Georgia inmate was postponed because the medicine (pentobarbital-Nembutal) to be used in the procedure appeared cloudy and therefore defective.  This is a medicine in the barbiturate family of medicines usually used  as a second line medicine in seizures. The package insert for Nembutal clearly states that itravenous solutions that appear cloudy should NEVER be used.

A pharmacist was apparently called in to examine the product and did the correct thing. There may not have been an acceptable replacement dose on hand. While this editor dosn't know the required state rules are in such a situation (Nembbutal is the ONLY acceptable drug for lethal injection in georgia). The execution was rescheduled.

I will be covering pentobarbital (Nembutal) in the upcoming 25th edition of The Essential Guiide to Prescription Drugs.

New essential Guide to Prescription Drugs, Update on Alcohol communicates author concerns

The new Essential Guide to Prescription Drugs, Update on Alcohol will help bring detailed information ot patients and families about crucial alcohol drug interactions, impact of binge and risky drinking and much more.

Current national coverage is expanding. www.fox19.com/story/28217302/6-people-die-each-day-from

News on The essential Guide to Prescription Drugs, Update on alcohol now available

 

dr rybacki in white coat Ongoing news pick up of the release of the Essential Guide to Prescription Drugs, Update on alcohol (now available on Amazon) continues to spread.

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dr rybacki in white coat Ongoing news pick up of the release of the Essential Guide to Prescription Drugs, Update on alcohol (now available on Amazon) continues to spread.

Essential Guide eBook seeks to prevent interactions  - KEYC - Mankato News, Weather, Sports - http://www.keyc.com/story/28217302/6-people-die-each-day-from-alcohol-poisoning-new-essential-guide-to-prescription-drugs-ebook-seeks-to-prevent-interactions-and-deaths#.VPFFRnzoZPs.twitter

This website is not intended as medical advice, and you should consult your doctor before changing or adding any medicines or vitamins to those you may now be taking and about applying any strategies BEFORE you adopt any approach in this report. While diligent care has been taken to ensure the accuracy of the information provided during the preparation of this edition, no claim is made that all known actions, uses or side effects, strategies for cost containment, targets or cholesterol pathways are included in this report. The accuracy and currentness of information are ever subject to change relative to new guidelines, new information derived from drug research, development and general usage.