High Blood Pressure

Mysimba (Contrave-Naltexone plus bupropion in the EU) now approved for weight loss

Mysimba for weight loss- It is the name for Contrave (naltrexone and bupropion) in Europe. This drug is the newest weight loss drug and had an unusual release of data. What appears to be shown in early data is that it may have a direct effect/benefit in decreasing risk of heart attack.

Palcohol powdered alcohol approved and now not approved

 

young women drinking Palcohol. Powdered alcohol. Convenient for hikers, kayakers, anywhere where weight is an issue, but could the very convenience it brings increase risk of alcohol poisoning and under age drinking?

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young women drinking Palcohol. Powdered alcohol. Convenient for hikers, kayakers, anywhere where weight is an issue, but could the very convenience it brings increase risk of alcohol poisoning and under age drinking?

These appear to be the challenges that Lipsmark, the company that makes Palcohol and Mark Phillips, the company president are now facing.

In a recent interview, the president noted that he came up with the idea for use in hiking and wanting to enjoy an alcoholic beverage when the day is done. One of the Rum, Vodka, Cosmopolitan or Powderita packets apparently has as much alcohol as a typical drink. The prevalent video shows Mr. Phillips reconstituting a packet, then pouring a drink.

 

Concerns arose in the media and from legislators almost immediately. Colorado and several other states banned the product. Approval for the product apparently has been reversed.

This editor immediately had the caution reaction, noting that the recently released Essential Guide to Prescription Drugs, Update on Alcohol helps people understand how to drink safely and avoid interactions, but that the book didn't contain Palcohol data (except in the sense of a standard drink and being careful of intake).

 

The saga of Palcohol is not over, but is apprently being reviewed. There are several cases of prescription drugs where medguides (and perhaps the Essential Guide) could be used to teach people about the product and help avoid problems. Perhaps a limitation on sales (5 packets at a time to any single person) could help.

 

More to follow as always once new information becomes available.

Contrave and cardiology--could this newer weight loss drug help your heart too?

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food Contrave (bupropion and naltrexone) is apparently unique. The SEC disclosed that the US patent office gave the 371 patent to Orexigen Therapeutics based on an interim look at the LIGHT study. What this means is that Contrave has a claim for having a POSITIVE IMPACT on cardiovascular results (outcomes) beyond (unrelated to) weight loss.

More to come and most probably from the American College of Cardiology meeting in San Diego this month. Regardless, having strength in weight loss AND HEART disease is a true breakthrough in medicines.

New essential Guide to Prescription Drugs, Update on Alcohol communicates author concerns

The new Essential Guide to Prescription Drugs, Update on Alcohol will help bring detailed information ot patients and families about crucial alcohol drug interactions, impact of binge and risky drinking and much more.

Current national coverage is expanding. www.fox19.com/story/28217302/6-people-die-each-day-from

News on The essential Guide to Prescription Drugs, Update on alcohol now available

 

dr rybacki in white coat Ongoing news pick up of the release of the Essential Guide to Prescription Drugs, Update on alcohol (now available on Amazon) continues to spread.

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dr rybacki in white coat Ongoing news pick up of the release of the Essential Guide to Prescription Drugs, Update on alcohol (now available on Amazon) continues to spread.

Essential Guide eBook seeks to prevent interactions  - KEYC - Mankato News, Weather, Sports - http://www.keyc.com/story/28217302/6-people-die-each-day-from-alcohol-poisoning-new-essential-guide-to-prescription-drugs-ebook-seeks-to-prevent-interactions-and-deaths#.VPFFRnzoZPs.twitter

New Essential Guide to Prescription Drugs, Upddate on Alcohol delves into alcohol poisoning and avoiding it

    two women drinking Roughly 130 million people in the US drink alcoholic beverages and many of us take alcohol for granted. Recent data compiled from the CDC reveal that roughly 6 people die a day from aclohol poisoning.

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    two women drinking Roughly 130 million people in the US drink alcoholic beverages and many of us take alcohol for granted. Recent data compiled from the CDC reveal that roughly 6 people die a day from aclohol poisoning. This sad and largely preventable death toll is related to the blood level of alcohol and also to potential drug interactions.

Surprisingly, alcohol is actually used for antifreeze poisoning, but is far more commonly used as an antianxiety/relaxation agent. So many of us know that after work cocktail or two and the effects of a drink and how it works--or do we? James Rybacki, the author of a new book on alcohol, entitles, The Essential Guide to Prescription Drugs, Update on alcohol (available from Amazon exclusively at present) was shocked to learn of the large daily number of deaths from such a common beverage. More importantly, when the new became available, he decided to update his prior publication (previously only available as a PDF) and launched a large awareness campaign to help people and thier children become more aware of risky drinking, binge drinking and important facts to help keep people safe.

While the eBook, The Essential Guide to Prescription Drugs, Update on Alcohol is currently only available from Amazon for Kindle, it will soom be available in the iBookstore and other outlets. Rybacki is quotes as saying, "the best colleague any clinician can have is a more fully informed patient and family." Very true words when it comes to alcohol.Find the book at Amazon and listed in Dr. Rybacki's vast publication list as the latest one at https://www.amazon.com/author/jamesrybacki.

FDA announces easier road and forms for experimental (investigational) medicines

 

The FDA IS listening

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The FDA IS listening

last resort Dr. Peter Lurie from the FDA announced a large step to help people looking to investigational medicines to treat serious diseases and conditions. The FDA listened well to the vulnerable patients and to physicians trying to navigate what was a complicated course to treatment.

The new draft document is called the Individual Patient expanded Access Applications: Form FDA 3926. This is complicated in the name alone. When the process is finalized, the form will immensely simplify and accelerate the process that your doctor will have to use to get an experimental (in FDA lingo-investigational) drug or biological treatment while it is still being tested to establish safety and efficacy. As usual, I will detail the true breakthroughs in medicines and those with particular interest in The Essential Guide to Prescription Drugs.

The form is still detailed, but FDA estimates hold that a doctor will need 45 minutes versus 100 HOURS to fill in the information. Nice move from the FDA at a time when physicians and patient just want a better way to attack disease. blogs.fda.gov/fdavoice/index.php/2015/02/a-big-step-to-help-the-patients-most-in-need/

Is the FDA keeping medical devices safe?

 

Is the FDA keeping medical devices safe?

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Is the FDA keeping medical devices safe?

A new program appears to be aimed at further accomplishing exactly that. The name is MDSAP (Medical Device Single Audit Program) It could be a milestone in that people who make medical equipment and  want to sell their products in Australia, Brazil, Canada, the US and Japan. The concept seeks to have a single audit or inspection to ensure that the medical device regulatory requirements are met.

Reviews (audits) will be conducted by third party vendors and medical device regulators in the countries will be able to use these inspection reports to make their regulatory decisions. It looks like the program would standardize the information the regulators get and will reduce the need to perform routine inspections. The people who make the medical equipment may benefit by cutting down on the number of regulatory audits they have to host, letting them keep their plants active making the products they want to sell.

Time will tell if this new MDSAP will be a win win for everyone, but it appears to be just the ticket for a more standard review and fewer inspections, yet better products.  

This website is not intended as medical advice, and you should consult your doctor before changing or adding any medicines or vitamins to those you may now be taking and about applying any strategies BEFORE you adopt any approach in this report. While diligent care has been taken to ensure the accuracy of the information provided during the preparation of this edition, no claim is made that all known actions, uses or side effects, strategies for cost containment, targets or cholesterol pathways are included in this report. The accuracy and currentness of information are ever subject to change relative to new guidelines, new information derived from drug research, development and general usage.