Heart Attacks

Did you get your flu vaccination yet? How about today?

beach scene There you were sitting on the beach. Where does the time go? Summer is over now and the leaves are starting to fall. I got my flu shot yesterday. How about you?

Shock at the Pharmacy Drive Up Window

Something is fishy  After lunch I stopped at a large Pharmacy chain to hand in 2 written prescriptions and to ask for a refill on one of the other prescriptions that my doctor had just called in. Three prescriptions, nothing unusual. (little did I know, something was fishy).

Mysimba (Contrave-Naltexone plus bupropion in the EU) now approved for weight loss

Mysimba for weight loss- It is the name for Contrave (naltrexone and bupropion) in Europe. This drug is the newest weight loss drug and had an unusual release of data. What appears to be shown in early data is that it may have a direct effect/benefit in decreasing risk of heart attack.

Palcohol powdered alcohol approved and now not approved


young women drinking Palcohol. Powdered alcohol. Convenient for hikers, kayakers, anywhere where weight is an issue, but could the very convenience it brings increase risk of alcohol poisoning and under age drinking?

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young women drinking Palcohol. Powdered alcohol. Convenient for hikers, kayakers, anywhere where weight is an issue, but could the very convenience it brings increase risk of alcohol poisoning and under age drinking?

These appear to be the challenges that Lipsmark, the company that makes Palcohol and Mark Phillips, the company president are now facing.

In a recent interview, the president noted that he came up with the idea for use in hiking and wanting to enjoy an alcoholic beverage when the day is done. One of the Rum, Vodka, Cosmopolitan or Powderita packets apparently has as much alcohol as a typical drink. The prevalent video shows Mr. Phillips reconstituting a packet, then pouring a drink.


Concerns arose in the media and from legislators almost immediately. Colorado and several other states banned the product. Approval for the product apparently has been reversed.

This editor immediately had the caution reaction, noting that the recently released Essential Guide to Prescription Drugs, Update on Alcohol helps people understand how to drink safely and avoid interactions, but that the book didn't contain Palcohol data (except in the sense of a standard drink and being careful of intake).


The saga of Palcohol is not over, but is apprently being reviewed. There are several cases of prescription drugs where medguides (and perhaps the Essential Guide) could be used to teach people about the product and help avoid problems. Perhaps a limitation on sales (5 packets at a time to any single person) could help.


More to follow as always once new information becomes available.

Weight loss drug decreases heart attacks? Contrave and early data


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fireworks A study of 4,500 patients using a new weight loss drug called Contrave (bupriprion and naltrexone) had the expected effect of a weight loss benefit, and the drug was FDA approved. A study of 8,910 people in a follow up study had the weight loss benefit, however; the patients taking Contrave had fewer heart attacks than the people who didn't take it.

There is controversy over this trial and apparent early leaks of data, but the information that patients taking the drug had fewer heart attacks is stunning. Importantly, the researchers doing the study thought the benefit on heart attacks may be a direct effect of the drug combination!

More to follow as always.

Contrave and cardiology--could this newer weight loss drug help your heart too?


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food Contrave (bupropion and naltrexone) is apparently unique. The SEC disclosed that the US patent office gave the 371 patent to Orexigen Therapeutics based on an interim look at the LIGHT study. What this means is that Contrave has a claim for having a POSITIVE IMPACT on cardiovascular results (outcomes) beyond (unrelated to) weight loss.

More to come and most probably from the American College of Cardiology meeting in San Diego this month. Regardless, having strength in weight loss AND HEART disease is a true breakthrough in medicines.

This website is not intended as medical advice, and you should consult your doctor before changing or adding any medicines or vitamins to those you may now be taking and about applying any strategies BEFORE you adopt any approach in this report. While diligent care has been taken to ensure the accuracy of the information provided during the preparation of this edition, no claim is made that all known actions, uses or side effects, strategies for cost containment, targets or cholesterol pathways are included in this report. The accuracy and currentness of information are ever subject to change relative to new guidelines, new information derived from drug research, development and general usage.